Positron Emission Tomogragraphy

Positron Emission Tomographic Scanning of Human Cardiac Sympathetic Nerves with 18F-labeled Fluorodopamine



Positron emission tomographic scanning the heart using 18F-labeled-fluorodopamine as an imaging agent enables non-invasive visualization of the sympathetic nerves innervating the human myocardium. The approach allows detection of regional abnormalities in sympathetic innervation that may be associated with diseases of the heart, such as hypertrophic cardiomyopathy, ischemic heart disease, cardiac failure, ventricular arrythmias and dysautonomias. PET scanning with 18F-labeled fluorodopamine combined with radiotracer-kinetic analysis of cardiac sympathetic function offers powerful methodology to examine involvement of the sympathetic nervous system in diseases of the human heart.


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