What is the extended Ogston model?

The extended Ogston model probabilistically describes the migration of a particle through a random and inert network of non-flexible fibers (gel matrix) on the basis of the fractional volume that is available to the migrating particle. This volume is determined by the particle radius, R, as well as the fiber radius, r, and specific fiber length, l' (cm/g). Using these rationales, one can derive the equation underlying the Ferguson plot.

Ogston, A.G., Trans Farady Soc. 1958, 54, 1754-1757

Rodbard, D., Chrambach, A., Proc. Natl. Acad. Sci. USA, 1970, 65, 970-977

Tietz, D., Adv. Electrophoresis 1988, 2, 109-169

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